The development of vaccine viruses against pandemic A(H1N1) influenza
Identifieur interne : 002A32 ( Main/Exploration ); précédent : 002A31; suivant : 002A33The development of vaccine viruses against pandemic A(H1N1) influenza
Auteurs : James S. Robertson [Royaume-Uni] ; Carolyn Nicolson [Royaume-Uni] ; Ruth Harvey [Royaume-Uni] ; Rachel Johnson [Royaume-Uni] ; Diane Major [Royaume-Uni] ; Kate Guilfoyle [Royaume-Uni] ; Sarah Roseby [Royaume-Uni] ; Robert Newman [Royaume-Uni] ; Rebecca Collin [Royaume-Uni] ; Chantal Wallis [Royaume-Uni] ; Othmar G. Engelhardt [Royaume-Uni] ; John M. Wood [Royaume-Uni] ; JIANHUA LE [États-Unis] ; Ramanunninair Manojkumar [États-Unis] ; Barbara A. Pokorny [États-Unis] ; Jeanmarie Silverman [États-Unis] ; Rene Devis [États-Unis] ; Doris Bucher [États-Unis] ; Erin Verity [Australie] ; Catherine Agius [Australie] ; Sarina Camuglia [Australie] ; Chi Ong [Australie] ; Steven Rockman [Australie] ; Anne Curtis [Australie] ; Peter Schoofs [Australie] ; Olga Zoueva [États-Unis] ; HANG XIE [États-Unis] ; XING LI [États-Unis] ; ZHENGSHI LIN [États-Unis] ; ZHIPIN GYE [États-Unis] ; Li-Mei Chen [États-Unis] ; Eduardo O'Neill [États-Unis] ; Amanda Balish [États-Unis] ; Aleksandr S. Lipatov [États-Unis] ; ZHU GUO [États-Unis] ; Irina Isakova [États-Unis] ; Charles T. Davis [États-Unis] ; Pierre Rivailler [États-Unis] ; Kortney M. Gustin [États-Unis] ; Jessica A. Belser [États-Unis] ; Taronna R. Maines [États-Unis] ; Terrence M. Tumpey [États-Unis] ; XIYAN XU [États-Unis] ; Jacqueline M. Katz [États-Unis] ; Alexander Klimov [États-Unis] ; Nancy J. Cox [États-Unis] ; Ruben O. Donis [États-Unis]Source :
- Vaccine [ 0264-410X ] ; 2011.
Descripteurs français
- Pascal (Inist)
- Wicri :
English descriptors
- KwdEn :
Abstract
Wild type human influenza viruses do not usually grow well in embryonated hens' eggs, the substrate of choice for the production of inactivated influenza vaccine, and vaccine viruses need to be developed specifically for this purpose. In the event of a pandemic of influenza, vaccine viruses need to be created with utmost speed. At the onset of the current A(H1N1) pandemic in April 2009, a network of laboratories began a race against time to develop suitable candidate vaccine viruses. Two approaches were followed, the classical reassortment approach and the more recent reverse genetics approach. This report describes the development and the characteristics of current pandemic H1N1 candidate vaccine viruses.
Affiliations:
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Tumpey</name><affiliation wicri:level="2"><inist:fA14 i1="05"><s1>Influenza Division, Centers for Disease Control and Prevention</s1><s2>Atlanta, GA 30333</s2><s3>USA</s3><sZ>31 aut.</sZ><sZ>32 aut.</sZ><sZ>33 aut.</sZ><sZ>34 aut.</sZ><sZ>35 aut.</sZ><sZ>36 aut.</sZ><sZ>37 aut.</sZ><sZ>38 aut.</sZ><sZ>39 aut.</sZ><sZ>40 aut.</sZ><sZ>41 aut.</sZ><sZ>42 aut.</sZ><sZ>43 aut.</sZ><sZ>44 aut.</sZ><sZ>45 aut.</sZ><sZ>46 aut.</sZ><sZ>47 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Xiyan Xu" sort="Xiyan Xu" uniqKey="Xiyan Xu" last="Xiyan Xu">XIYAN XU</name><affiliation wicri:level="2"><inist:fA14 i1="05"><s1>Influenza Division, Centers for Disease Control and Prevention</s1><s2>Atlanta, GA 30333</s2><s3>USA</s3><sZ>31 aut.</sZ><sZ>32 aut.</sZ><sZ>33 aut.</sZ><sZ>34 aut.</sZ><sZ>35 aut.</sZ><sZ>36 aut.</sZ><sZ>37 aut.</sZ><sZ>38 aut.</sZ><sZ>39 aut.</sZ><sZ>40 aut.</sZ><sZ>41 aut.</sZ><sZ>42 aut.</sZ><sZ>43 aut.</sZ><sZ>44 aut.</sZ><sZ>45 aut.</sZ><sZ>46 aut.</sZ><sZ>47 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Katz, Jacqueline M" sort="Katz, Jacqueline M" uniqKey="Katz J" first="Jacqueline M." last="Katz">Jacqueline M. Katz</name><affiliation wicri:level="2"><inist:fA14 i1="05"><s1>Influenza Division, Centers for Disease Control and Prevention</s1><s2>Atlanta, GA 30333</s2><s3>USA</s3><sZ>31 aut.</sZ><sZ>32 aut.</sZ><sZ>33 aut.</sZ><sZ>34 aut.</sZ><sZ>35 aut.</sZ><sZ>36 aut.</sZ><sZ>37 aut.</sZ><sZ>38 aut.</sZ><sZ>39 aut.</sZ><sZ>40 aut.</sZ><sZ>41 aut.</sZ><sZ>42 aut.</sZ><sZ>43 aut.</sZ><sZ>44 aut.</sZ><sZ>45 aut.</sZ><sZ>46 aut.</sZ><sZ>47 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Klimov, Alexander" sort="Klimov, Alexander" uniqKey="Klimov A" first="Alexander" last="Klimov">Alexander Klimov</name><affiliation wicri:level="2"><inist:fA14 i1="05"><s1>Influenza Division, Centers for Disease Control and Prevention</s1><s2>Atlanta, GA 30333</s2><s3>USA</s3><sZ>31 aut.</sZ><sZ>32 aut.</sZ><sZ>33 aut.</sZ><sZ>34 aut.</sZ><sZ>35 aut.</sZ><sZ>36 aut.</sZ><sZ>37 aut.</sZ><sZ>38 aut.</sZ><sZ>39 aut.</sZ><sZ>40 aut.</sZ><sZ>41 aut.</sZ><sZ>42 aut.</sZ><sZ>43 aut.</sZ><sZ>44 aut.</sZ><sZ>45 aut.</sZ><sZ>46 aut.</sZ><sZ>47 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Cox, Nancy J" sort="Cox, Nancy J" uniqKey="Cox N" first="Nancy J." last="Cox">Nancy J. Cox</name><affiliation wicri:level="2"><inist:fA14 i1="05"><s1>Influenza Division, Centers for Disease Control and Prevention</s1><s2>Atlanta, GA 30333</s2><s3>USA</s3><sZ>31 aut.</sZ><sZ>32 aut.</sZ><sZ>33 aut.</sZ><sZ>34 aut.</sZ><sZ>35 aut.</sZ><sZ>36 aut.</sZ><sZ>37 aut.</sZ><sZ>38 aut.</sZ><sZ>39 aut.</sZ><sZ>40 aut.</sZ><sZ>41 aut.</sZ><sZ>42 aut.</sZ><sZ>43 aut.</sZ><sZ>44 aut.</sZ><sZ>45 aut.</sZ><sZ>46 aut.</sZ><sZ>47 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Donis, Ruben O" sort="Donis, Ruben O" uniqKey="Donis R" first="Ruben O." last="Donis">Ruben O. Donis</name><affiliation wicri:level="2"><inist:fA14 i1="05"><s1>Influenza Division, Centers for Disease Control and Prevention</s1><s2>Atlanta, GA 30333</s2><s3>USA</s3><sZ>31 aut.</sZ><sZ>32 aut.</sZ><sZ>33 aut.</sZ><sZ>34 aut.</sZ><sZ>35 aut.</sZ><sZ>36 aut.</sZ><sZ>37 aut.</sZ><sZ>38 aut.</sZ><sZ>39 aut.</sZ><sZ>40 aut.</sZ><sZ>41 aut.</sZ><sZ>42 aut.</sZ><sZ>43 aut.</sZ><sZ>44 aut.</sZ><sZ>45 aut.</sZ><sZ>46 aut.</sZ><sZ>47 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">11-0364688</idno><date when="2011">2011</date><idno type="stanalyst">PASCAL 11-0364688 INIST</idno><idno type="RBID">Pascal:11-0364688</idno><idno type="wicri:Area/PascalFrancis/Corpus">000A84</idno><idno type="wicri:Area/PascalFrancis/Curation">001371</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000878</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000878</idno><idno type="wicri:doubleKey">0264-410X:2011:Robertson J:the:development:of</idno><idno type="wicri:Area/Main/Merge">002B32</idno><idno type="wicri:Area/Main/Curation">002A32</idno><idno type="wicri:Area/Main/Exploration">002A32</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">The development of vaccine viruses against pandemic A(H1N1) influenza</title><author><name sortKey="Robertson, James S" sort="Robertson, James S" uniqKey="Robertson J" first="James S." last="Robertson">James S. Robertson</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division of Virology, National Institute for Biological Standards and Control, Blanche Lane, South Mimms</s1><s2>Potters Bar EN6 3QG</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Potters Bar EN6 3QG</wicri:noRegion></affiliation></author><author><name sortKey="Nicolson, Carolyn" sort="Nicolson, Carolyn" uniqKey="Nicolson C" first="Carolyn" last="Nicolson">Carolyn Nicolson</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division of Virology, National Institute for Biological Standards and Control, Blanche Lane, South Mimms</s1><s2>Potters Bar EN6 3QG</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Potters Bar EN6 3QG</wicri:noRegion></affiliation></author><author><name sortKey="Harvey, Ruth" sort="Harvey, Ruth" uniqKey="Harvey R" first="Ruth" last="Harvey">Ruth Harvey</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division of Virology, National Institute for Biological Standards and Control, Blanche Lane, South Mimms</s1><s2>Potters Bar EN6 3QG</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Potters Bar EN6 3QG</wicri:noRegion></affiliation></author><author><name sortKey="Johnson, Rachel" sort="Johnson, Rachel" uniqKey="Johnson R" first="Rachel" last="Johnson">Rachel Johnson</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division of Virology, National Institute for Biological Standards and Control, Blanche Lane, South Mimms</s1><s2>Potters Bar EN6 3QG</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Potters Bar EN6 3QG</wicri:noRegion></affiliation></author><author><name sortKey="Major, Diane" sort="Major, Diane" uniqKey="Major D" first="Diane" last="Major">Diane Major</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division of Virology, National Institute for Biological Standards and Control, Blanche Lane, South Mimms</s1><s2>Potters Bar EN6 3QG</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Potters Bar EN6 3QG</wicri:noRegion></affiliation></author><author><name sortKey="Guilfoyle, Kate" sort="Guilfoyle, Kate" uniqKey="Guilfoyle K" first="Kate" last="Guilfoyle">Kate Guilfoyle</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division of Virology, National Institute for Biological Standards and Control, Blanche Lane, South Mimms</s1><s2>Potters Bar EN6 3QG</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Potters Bar EN6 3QG</wicri:noRegion></affiliation></author><author><name sortKey="Roseby, Sarah" sort="Roseby, Sarah" uniqKey="Roseby S" first="Sarah" last="Roseby">Sarah Roseby</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division of Virology, National Institute for Biological Standards and Control, Blanche Lane, South Mimms</s1><s2>Potters Bar EN6 3QG</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Potters Bar EN6 3QG</wicri:noRegion></affiliation></author><author><name sortKey="Newman, Robert" sort="Newman, Robert" uniqKey="Newman R" first="Robert" last="Newman">Robert Newman</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division of Virology, National Institute for Biological Standards and Control, Blanche Lane, South Mimms</s1><s2>Potters Bar EN6 3QG</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Potters Bar EN6 3QG</wicri:noRegion></affiliation></author><author><name sortKey="Collin, Rebecca" sort="Collin, Rebecca" uniqKey="Collin R" first="Rebecca" last="Collin">Rebecca Collin</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division of Virology, National Institute for Biological Standards and Control, Blanche Lane, South Mimms</s1><s2>Potters Bar EN6 3QG</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Potters Bar EN6 3QG</wicri:noRegion></affiliation></author><author><name sortKey="Wallis, Chantal" sort="Wallis, Chantal" uniqKey="Wallis C" first="Chantal" last="Wallis">Chantal Wallis</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division of Virology, National Institute for Biological Standards and Control, Blanche Lane, South Mimms</s1><s2>Potters Bar EN6 3QG</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Potters Bar EN6 3QG</wicri:noRegion></affiliation></author><author><name sortKey="Engelhardt, Othmar G" sort="Engelhardt, Othmar G" uniqKey="Engelhardt O" first="Othmar G." last="Engelhardt">Othmar G. Engelhardt</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division of Virology, National Institute for Biological Standards and Control, Blanche Lane, South Mimms</s1><s2>Potters Bar EN6 3QG</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Potters Bar EN6 3QG</wicri:noRegion></affiliation></author><author><name sortKey="Wood, John M" sort="Wood, John M" uniqKey="Wood J" first="John M." last="Wood">John M. Wood</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division of Virology, National Institute for Biological Standards and Control, Blanche Lane, South Mimms</s1><s2>Potters Bar EN6 3QG</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Potters Bar EN6 3QG</wicri:noRegion></affiliation></author><author><name sortKey="Jianhua Le" sort="Jianhua Le" uniqKey="Jianhua Le" last="Jianhua Le">JIANHUA LE</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Microbiology and Immunology, New York Medical College</s1><s2>Valhalla, NY 10595</s2><s3>USA</s3><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Manojkumar, Ramanunninair" sort="Manojkumar, Ramanunninair" uniqKey="Manojkumar R" first="Ramanunninair" last="Manojkumar">Ramanunninair Manojkumar</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Microbiology and Immunology, New York Medical College</s1><s2>Valhalla, NY 10595</s2><s3>USA</s3><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Pokorny, Barbara A" sort="Pokorny, Barbara A" uniqKey="Pokorny B" first="Barbara A." last="Pokorny">Barbara A. Pokorny</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Microbiology and Immunology, New York Medical College</s1><s2>Valhalla, NY 10595</s2><s3>USA</s3><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Silverman, Jeanmarie" sort="Silverman, Jeanmarie" uniqKey="Silverman J" first="Jeanmarie" last="Silverman">Jeanmarie Silverman</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Microbiology and Immunology, New York Medical College</s1><s2>Valhalla, NY 10595</s2><s3>USA</s3><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Devis, Rene" 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Davis</name><affiliation wicri:level="2"><inist:fA14 i1="05"><s1>Influenza Division, Centers for Disease Control and Prevention</s1><s2>Atlanta, GA 30333</s2><s3>USA</s3><sZ>31 aut.</sZ><sZ>32 aut.</sZ><sZ>33 aut.</sZ><sZ>34 aut.</sZ><sZ>35 aut.</sZ><sZ>36 aut.</sZ><sZ>37 aut.</sZ><sZ>38 aut.</sZ><sZ>39 aut.</sZ><sZ>40 aut.</sZ><sZ>41 aut.</sZ><sZ>42 aut.</sZ><sZ>43 aut.</sZ><sZ>44 aut.</sZ><sZ>45 aut.</sZ><sZ>46 aut.</sZ><sZ>47 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Rivailler, Pierre" sort="Rivailler, Pierre" uniqKey="Rivailler P" first="Pierre" last="Rivailler">Pierre Rivailler</name><affiliation wicri:level="2"><inist:fA14 i1="05"><s1>Influenza Division, Centers for Disease Control and Prevention</s1><s2>Atlanta, GA 30333</s2><s3>USA</s3><sZ>31 aut.</sZ><sZ>32 aut.</sZ><sZ>33 aut.</sZ><sZ>34 aut.</sZ><sZ>35 aut.</sZ><sZ>36 aut.</sZ><sZ>37 aut.</sZ><sZ>38 aut.</sZ><sZ>39 aut.</sZ><sZ>40 aut.</sZ><sZ>41 aut.</sZ><sZ>42 aut.</sZ><sZ>43 aut.</sZ><sZ>44 aut.</sZ><sZ>45 aut.</sZ><sZ>46 aut.</sZ><sZ>47 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Gustin, Kortney M" sort="Gustin, Kortney M" uniqKey="Gustin K" first="Kortney M." last="Gustin">Kortney M. Gustin</name><affiliation wicri:level="2"><inist:fA14 i1="05"><s1>Influenza Division, Centers for Disease Control and Prevention</s1><s2>Atlanta, GA 30333</s2><s3>USA</s3><sZ>31 aut.</sZ><sZ>32 aut.</sZ><sZ>33 aut.</sZ><sZ>34 aut.</sZ><sZ>35 aut.</sZ><sZ>36 aut.</sZ><sZ>37 aut.</sZ><sZ>38 aut.</sZ><sZ>39 aut.</sZ><sZ>40 aut.</sZ><sZ>41 aut.</sZ><sZ>42 aut.</sZ><sZ>43 aut.</sZ><sZ>44 aut.</sZ><sZ>45 aut.</sZ><sZ>46 aut.</sZ><sZ>47 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Belser, Jessica A" sort="Belser, Jessica A" uniqKey="Belser J" first="Jessica A." last="Belser">Jessica A. Belser</name><affiliation wicri:level="2"><inist:fA14 i1="05"><s1>Influenza Division, Centers for Disease Control and Prevention</s1><s2>Atlanta, GA 30333</s2><s3>USA</s3><sZ>31 aut.</sZ><sZ>32 aut.</sZ><sZ>33 aut.</sZ><sZ>34 aut.</sZ><sZ>35 aut.</sZ><sZ>36 aut.</sZ><sZ>37 aut.</sZ><sZ>38 aut.</sZ><sZ>39 aut.</sZ><sZ>40 aut.</sZ><sZ>41 aut.</sZ><sZ>42 aut.</sZ><sZ>43 aut.</sZ><sZ>44 aut.</sZ><sZ>45 aut.</sZ><sZ>46 aut.</sZ><sZ>47 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Maines, Taronna R" sort="Maines, Taronna R" uniqKey="Maines T" first="Taronna R." last="Maines">Taronna R. Maines</name><affiliation wicri:level="2"><inist:fA14 i1="05"><s1>Influenza Division, Centers for Disease Control and Prevention</s1><s2>Atlanta, GA 30333</s2><s3>USA</s3><sZ>31 aut.</sZ><sZ>32 aut.</sZ><sZ>33 aut.</sZ><sZ>34 aut.</sZ><sZ>35 aut.</sZ><sZ>36 aut.</sZ><sZ>37 aut.</sZ><sZ>38 aut.</sZ><sZ>39 aut.</sZ><sZ>40 aut.</sZ><sZ>41 aut.</sZ><sZ>42 aut.</sZ><sZ>43 aut.</sZ><sZ>44 aut.</sZ><sZ>45 aut.</sZ><sZ>46 aut.</sZ><sZ>47 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Tumpey, Terrence M" sort="Tumpey, Terrence M" uniqKey="Tumpey T" first="Terrence M." last="Tumpey">Terrence M. Tumpey</name><affiliation wicri:level="2"><inist:fA14 i1="05"><s1>Influenza Division, Centers for Disease Control and Prevention</s1><s2>Atlanta, GA 30333</s2><s3>USA</s3><sZ>31 aut.</sZ><sZ>32 aut.</sZ><sZ>33 aut.</sZ><sZ>34 aut.</sZ><sZ>35 aut.</sZ><sZ>36 aut.</sZ><sZ>37 aut.</sZ><sZ>38 aut.</sZ><sZ>39 aut.</sZ><sZ>40 aut.</sZ><sZ>41 aut.</sZ><sZ>42 aut.</sZ><sZ>43 aut.</sZ><sZ>44 aut.</sZ><sZ>45 aut.</sZ><sZ>46 aut.</sZ><sZ>47 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Xiyan Xu" sort="Xiyan Xu" uniqKey="Xiyan Xu" last="Xiyan Xu">XIYAN XU</name><affiliation wicri:level="2"><inist:fA14 i1="05"><s1>Influenza Division, Centers for Disease Control and Prevention</s1><s2>Atlanta, GA 30333</s2><s3>USA</s3><sZ>31 aut.</sZ><sZ>32 aut.</sZ><sZ>33 aut.</sZ><sZ>34 aut.</sZ><sZ>35 aut.</sZ><sZ>36 aut.</sZ><sZ>37 aut.</sZ><sZ>38 aut.</sZ><sZ>39 aut.</sZ><sZ>40 aut.</sZ><sZ>41 aut.</sZ><sZ>42 aut.</sZ><sZ>43 aut.</sZ><sZ>44 aut.</sZ><sZ>45 aut.</sZ><sZ>46 aut.</sZ><sZ>47 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Katz, Jacqueline M" sort="Katz, Jacqueline M" uniqKey="Katz J" first="Jacqueline M." last="Katz">Jacqueline M. Katz</name><affiliation wicri:level="2"><inist:fA14 i1="05"><s1>Influenza Division, Centers for Disease Control and Prevention</s1><s2>Atlanta, GA 30333</s2><s3>USA</s3><sZ>31 aut.</sZ><sZ>32 aut.</sZ><sZ>33 aut.</sZ><sZ>34 aut.</sZ><sZ>35 aut.</sZ><sZ>36 aut.</sZ><sZ>37 aut.</sZ><sZ>38 aut.</sZ><sZ>39 aut.</sZ><sZ>40 aut.</sZ><sZ>41 aut.</sZ><sZ>42 aut.</sZ><sZ>43 aut.</sZ><sZ>44 aut.</sZ><sZ>45 aut.</sZ><sZ>46 aut.</sZ><sZ>47 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Klimov, Alexander" sort="Klimov, Alexander" uniqKey="Klimov A" first="Alexander" last="Klimov">Alexander Klimov</name><affiliation wicri:level="2"><inist:fA14 i1="05"><s1>Influenza Division, Centers for Disease Control and Prevention</s1><s2>Atlanta, GA 30333</s2><s3>USA</s3><sZ>31 aut.</sZ><sZ>32 aut.</sZ><sZ>33 aut.</sZ><sZ>34 aut.</sZ><sZ>35 aut.</sZ><sZ>36 aut.</sZ><sZ>37 aut.</sZ><sZ>38 aut.</sZ><sZ>39 aut.</sZ><sZ>40 aut.</sZ><sZ>41 aut.</sZ><sZ>42 aut.</sZ><sZ>43 aut.</sZ><sZ>44 aut.</sZ><sZ>45 aut.</sZ><sZ>46 aut.</sZ><sZ>47 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Cox, Nancy J" sort="Cox, Nancy J" uniqKey="Cox N" first="Nancy J." last="Cox">Nancy J. Cox</name><affiliation wicri:level="2"><inist:fA14 i1="05"><s1>Influenza Division, Centers for Disease Control and Prevention</s1><s2>Atlanta, GA 30333</s2><s3>USA</s3><sZ>31 aut.</sZ><sZ>32 aut.</sZ><sZ>33 aut.</sZ><sZ>34 aut.</sZ><sZ>35 aut.</sZ><sZ>36 aut.</sZ><sZ>37 aut.</sZ><sZ>38 aut.</sZ><sZ>39 aut.</sZ><sZ>40 aut.</sZ><sZ>41 aut.</sZ><sZ>42 aut.</sZ><sZ>43 aut.</sZ><sZ>44 aut.</sZ><sZ>45 aut.</sZ><sZ>46 aut.</sZ><sZ>47 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Donis, Ruben O" sort="Donis, Ruben O" uniqKey="Donis R" first="Ruben O." last="Donis">Ruben O. Donis</name><affiliation wicri:level="2"><inist:fA14 i1="05"><s1>Influenza Division, Centers for Disease Control and Prevention</s1><s2>Atlanta, GA 30333</s2><s3>USA</s3><sZ>31 aut.</sZ><sZ>32 aut.</sZ><sZ>33 aut.</sZ><sZ>34 aut.</sZ><sZ>35 aut.</sZ><sZ>36 aut.</sZ><sZ>37 aut.</sZ><sZ>38 aut.</sZ><sZ>39 aut.</sZ><sZ>40 aut.</sZ><sZ>41 aut.</sZ><sZ>42 aut.</sZ><sZ>43 aut.</sZ><sZ>44 aut.</sZ><sZ>45 aut.</sZ><sZ>46 aut.</sZ><sZ>47 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Vaccine</title><title level="j" type="abbreviated">Vaccine</title><idno type="ISSN">0264-410X</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Vaccine</title><title level="j" type="abbreviated">Vaccine</title><idno type="ISSN">0264-410X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antigen</term><term>Genetic reassortment</term><term>Genetics</term><term>Influenza A</term><term>Influenza A virus</term><term>Vaccine</term><term>Yield</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Virus grippal A</term><term>Vaccin</term><term>Génétique</term><term>Antigène</term><term>Rendement</term><term>Grippe A</term><term>Réassortiment génétique</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Vaccin</term><term>Génétique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Wild type human influenza viruses do not usually grow well in embryonated hens' eggs, the substrate of choice for the production of inactivated influenza vaccine, and vaccine viruses need to be developed specifically for this purpose. In the event of a pandemic of influenza, vaccine viruses need to be created with utmost speed. At the onset of the current A(H1N1) pandemic in April 2009, a network of laboratories began a race against time to develop suitable candidate vaccine viruses. Two approaches were followed, the classical reassortment approach and the more recent reverse genetics approach. This report describes the development and the characteristics of current pandemic H1N1 candidate vaccine viruses.</div></front></TEI><affiliations><list><country><li>Australie</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Géorgie (États-Unis)</li><li>Maryland</li><li>État de New York</li></region></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Robertson, James S" sort="Robertson, James S" uniqKey="Robertson J" first="James S." last="Robertson">James S. Robertson</name></noRegion><name sortKey="Collin, Rebecca" sort="Collin, Rebecca" uniqKey="Collin R" first="Rebecca" last="Collin">Rebecca Collin</name><name sortKey="Engelhardt, Othmar G" sort="Engelhardt, Othmar G" uniqKey="Engelhardt O" first="Othmar G." last="Engelhardt">Othmar G. Engelhardt</name><name sortKey="Guilfoyle, Kate" sort="Guilfoyle, Kate" uniqKey="Guilfoyle K" first="Kate" last="Guilfoyle">Kate Guilfoyle</name><name sortKey="Harvey, Ruth" sort="Harvey, Ruth" uniqKey="Harvey R" first="Ruth" last="Harvey">Ruth Harvey</name><name sortKey="Johnson, Rachel" sort="Johnson, Rachel" uniqKey="Johnson R" first="Rachel" last="Johnson">Rachel Johnson</name><name sortKey="Major, Diane" sort="Major, Diane" uniqKey="Major D" first="Diane" last="Major">Diane Major</name><name sortKey="Newman, Robert" sort="Newman, Robert" uniqKey="Newman R" first="Robert" last="Newman">Robert Newman</name><name sortKey="Nicolson, Carolyn" sort="Nicolson, Carolyn" uniqKey="Nicolson C" first="Carolyn" last="Nicolson">Carolyn Nicolson</name><name sortKey="Roseby, Sarah" sort="Roseby, Sarah" uniqKey="Roseby S" first="Sarah" last="Roseby">Sarah Roseby</name><name sortKey="Wallis, Chantal" sort="Wallis, Chantal" uniqKey="Wallis C" first="Chantal" last="Wallis">Chantal Wallis</name><name sortKey="Wood, John M" sort="Wood, John M" uniqKey="Wood J" first="John M." last="Wood">John M. Wood</name></country><country name="États-Unis"><region name="État de New York"><name sortKey="Jianhua Le" sort="Jianhua Le" uniqKey="Jianhua Le" last="Jianhua Le">JIANHUA LE</name></region><name sortKey="Balish, Amanda" sort="Balish, Amanda" uniqKey="Balish A" first="Amanda" last="Balish">Amanda Balish</name><name sortKey="Belser, Jessica A" sort="Belser, Jessica A" uniqKey="Belser J" first="Jessica A." last="Belser">Jessica A. Belser</name><name sortKey="Bucher, Doris" sort="Bucher, Doris" uniqKey="Bucher D" first="Doris" last="Bucher">Doris Bucher</name><name sortKey="Chen, Li Mei" sort="Chen, Li Mei" uniqKey="Chen L" first="Li-Mei" last="Chen">Li-Mei Chen</name><name sortKey="Cox, Nancy J" sort="Cox, Nancy J" uniqKey="Cox N" first="Nancy J." last="Cox">Nancy J. Cox</name><name sortKey="Davis, Charles T" sort="Davis, Charles T" uniqKey="Davis C" first="Charles T." last="Davis">Charles T. Davis</name><name sortKey="Devis, Rene" sort="Devis, Rene" uniqKey="Devis R" first="Rene" last="Devis">Rene Devis</name><name sortKey="Donis, Ruben O" sort="Donis, Ruben O" uniqKey="Donis R" first="Ruben O." last="Donis">Ruben O. Donis</name><name sortKey="Gustin, Kortney M" sort="Gustin, Kortney M" uniqKey="Gustin K" first="Kortney M." last="Gustin">Kortney M. Gustin</name><name sortKey="Hang Xie" sort="Hang Xie" uniqKey="Hang Xie" last="Hang Xie">HANG XIE</name><name sortKey="Isakova, Irina" sort="Isakova, Irina" uniqKey="Isakova I" first="Irina" last="Isakova">Irina Isakova</name><name sortKey="Katz, Jacqueline M" sort="Katz, Jacqueline M" uniqKey="Katz J" first="Jacqueline M." last="Katz">Jacqueline M. Katz</name><name sortKey="Klimov, Alexander" sort="Klimov, Alexander" uniqKey="Klimov A" first="Alexander" last="Klimov">Alexander Klimov</name><name sortKey="Lipatov, Aleksandr S" sort="Lipatov, Aleksandr S" uniqKey="Lipatov A" first="Aleksandr S." last="Lipatov">Aleksandr S. Lipatov</name><name sortKey="Maines, Taronna R" sort="Maines, Taronna R" uniqKey="Maines T" first="Taronna R." last="Maines">Taronna R. Maines</name><name sortKey="Manojkumar, Ramanunninair" sort="Manojkumar, Ramanunninair" uniqKey="Manojkumar R" first="Ramanunninair" last="Manojkumar">Ramanunninair Manojkumar</name><name sortKey="O Neill, Eduardo" sort="O Neill, Eduardo" uniqKey="O Neill E" first="Eduardo" last="O'Neill">Eduardo O'Neill</name><name sortKey="Pokorny, Barbara A" sort="Pokorny, Barbara A" uniqKey="Pokorny B" first="Barbara A." last="Pokorny">Barbara A. Pokorny</name><name sortKey="Rivailler, Pierre" sort="Rivailler, Pierre" uniqKey="Rivailler P" first="Pierre" last="Rivailler">Pierre Rivailler</name><name sortKey="Silverman, Jeanmarie" sort="Silverman, Jeanmarie" uniqKey="Silverman J" first="Jeanmarie" last="Silverman">Jeanmarie Silverman</name><name sortKey="Tumpey, Terrence M" sort="Tumpey, Terrence M" uniqKey="Tumpey T" first="Terrence M." last="Tumpey">Terrence M. Tumpey</name><name sortKey="Xing Li" sort="Xing Li" uniqKey="Xing Li" last="Xing Li">XING LI</name><name sortKey="Xiyan Xu" sort="Xiyan Xu" uniqKey="Xiyan Xu" last="Xiyan Xu">XIYAN XU</name><name sortKey="Zhengshi Lin" sort="Zhengshi Lin" uniqKey="Zhengshi Lin" last="Zhengshi Lin">ZHENGSHI LIN</name><name sortKey="Zhipin Gye" sort="Zhipin Gye" uniqKey="Zhipin Gye" last="Zhipin Gye">ZHIPIN GYE</name><name sortKey="Zhu Guo" sort="Zhu Guo" uniqKey="Zhu Guo" last="Zhu Guo">ZHU GUO</name><name sortKey="Zoueva, Olga" sort="Zoueva, Olga" uniqKey="Zoueva O" first="Olga" last="Zoueva">Olga Zoueva</name></country><country name="Australie"><noRegion><name sortKey="Verity, Erin" sort="Verity, Erin" uniqKey="Verity E" first="Erin" last="Verity">Erin Verity</name></noRegion><name sortKey="Agius, Catherine" sort="Agius, Catherine" uniqKey="Agius C" first="Catherine" last="Agius">Catherine Agius</name><name sortKey="Camuglia, Sarina" sort="Camuglia, Sarina" uniqKey="Camuglia S" first="Sarina" last="Camuglia">Sarina Camuglia</name><name sortKey="Curtis, Anne" sort="Curtis, Anne" uniqKey="Curtis A" first="Anne" last="Curtis">Anne Curtis</name><name sortKey="Ong, Chi" sort="Ong, Chi" uniqKey="Ong C" first="Chi" last="Ong">Chi Ong</name><name sortKey="Rockman, Steven" sort="Rockman, Steven" uniqKey="Rockman S" first="Steven" last="Rockman">Steven Rockman</name><name sortKey="Schoofs, Peter" sort="Schoofs, Peter" uniqKey="Schoofs P" first="Peter" last="Schoofs">Peter Schoofs</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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